093. ATYPICAL PRESENTATION OF ANCA-ASSOCIATED VASCULITIS: A CASE SERIES

C-ANCA Positive Vasculitis in a Case of Amyloidosis

Case report An unusual presentation of C-ANCA vasculitis

A 54-year-old woman presented to casualty with left arm weakness, having had a preceding transient ischaemic episode in the same area and generalized flu-like symptoms a few days before admission. She had no traditional risk factors for vascular disease other than being an ex-smoker. Her National Institutes of Health Stroke Scale (NIHSS) score was 2 and an initial computerized tomography (CT) a...

Treatment of ANCA – Associated Vasculitis

ANCA – associated vasculitis (AAV) encompass Wegener granulomatosus (WG), Churg Strauss syndrome (CSS) and Microscopic Polyangiitis (MPA). Granuloma formation characterizes both WG and CSS, while necrotising inflammation of middle to small arteries, pauci-immune glomerulonephritis and production of ANCA typify all three of them. Common clinical and laboratory features point towards common patho...

Ofatumumab for B cell depletion therapy in ANCA-associated vasculitis: a single-centre case series

OBJECTIVES B cell depletion is an effective treatment strategy in ANCA-associated vasculitis (AAV). Ofatumumab is a fully humanized anti-CD20 mAb that has shown efficacy in the treatment of haematological malignancy and RA. The use of ofatumumab in the treatment of AAV has not previously been reported. METHODS This study was based on a case series of eight patients who received ofatumumab, in...

Epidemiology of ANCA associated vasculitis

ANCA associated vasculitis (AAV) comprises three syndromes with systemic vasculitis (Wegener’s granulomatosis (WG), Churg Strauss syndrome (CSS) and microscopic polyangiitis (MPA)), which all involve small and medium sized vessels and are associated with antibodies against cytoplasmatic antibodies in neutrophils (ANCA). Polyarteritis nodosa (PAN) is included in this review as it also affects me...